Silicon Nanoparticles as Amplifiers of the Ultrasonic Effect in Sonodynamic Therapy / Osminkina L. A.,Kudryavtsev A. A.,Zinovyev S. V.,Sviridov A. P.,Kargina Yu V.,Tamarov K. P.,Nikiforov V. N.,Ivanov A. V.,Vasilyev A. N.,Timoshenko V. Yu // BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE. - 2016. - V. 161, l. 2. - P. 296-299.

ISSN/EISSN:

0007-4888 / 1573-8221

Type:

Article

Abstract:

The possibility of using mesoporous silicon nanoparticles as amplifiers (sensitizers) of therapeutic ultrasonic exposure were studied experimentally in vitro and in vivo. The combination of nanoparticles and ultrasound led to a significant inhibition of Hep-2 cancer cell proliferation and Lewis lung carcinoma growth in mice. These results indicated good prospects of using silicon nanoparticles as sensitizers for sonodynamic therapy of tumors.

Author keywords:

ultrasound; nanoparticles; tumor; sonodynamic therapy CANCER-THERAPY; SONOSENSITIZERS; NANOCRYSTALS

DOI:

10.1007/s10517-016-3399-x

Web of Science ID:

ISI:000380118500023

Соавторы в МНС:

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Другие поля

Поле	Значение
Month	JUN
Publisher	SPRINGER
Address	233 SPRING ST, NEW YORK, NY 10013 USA
Language	English
EISSN	1573-8221
Keywords-Plus	CANCER-THERAPY; SONOSENSITIZERS; NANOCRYSTALS
Research-Areas	Research \& Experimental Medicine
Web-of-Science-Categories	Medicine, Research \& Experimental
Author-Email	osminkina@mig.phys.msu.ru
ResearcherID-Numbers	Kargina, Yulia/B-4509-2017 Osminkina, Liubov/G-6391-2014 Timoshenko, Victor/G-9860-2013 Nikiforov, Vladimir/G-5649-2010
ORCID-Numbers	Nikiforov, Vladimir/0000-0002-6153-2188 Osminkina, Liubov/0000-0001-7485-0495 Sviridov, Andrey/0000-0001-9618-5588
Funding-Acknowledgement	Russian Science Foundation {[}14-50-00029]
Funding-Text	The study was supported by the Russian Science Foundation (project No. 14-50-00029).
Number-of-Cited-References	11
Usage-Count-Last-180-days	2
Usage-Count-Since-2013	9
Journal-ISO	Bull. Exp. Biol. Med.
Doc-Delivery-Number	DR7ZP