PHLIP-modified magnetic nanoparticles for targeting acidic diseased tissue / Demin A.M., Pershina A.G., Nevskaya K.V., Efimova L.V., Shchegoleva N.N., Uimin M.A., Kuznetsov D.K., Shur V.Y., Krasnov V.P., Ogorodova L.M. // RSC Advances. - 2016. - V. 6, l. 65. - P. 60196-60199.

ISSN:
20462069
Type:
Article
Abstract:
Covalent immobilization of a pH-low insertion peptide (pHLIP) onto Fe3O4 magnetic nanoparticles was carried out resulting in the formation of MRI-visible materials able to specifically accumulate in acidic damaged tissue. The pH-dependent pHLIP-mediated binding of the obtained nanoconjugates to cells in acidic environment was demonstrated on HTC cells in vitro and in a mouse LLC tumour model in vivo. © 2016 The Royal Society of Chemistry.
Author keywords:
Index keywords:
Nanoparticles; Tissue; Acidic environment; Covalent immobilization; Diseased tissues; In-vitro; In-vivo; Magnetic nano-particles; PH-dependent; Nanomagnetics
DOI:
10.1039/c6ra13178f
Смотреть в Scopus:
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84976640760&doi=10.1039%2fc6ra13178f&partnerID=40&md5=c0abd66cff8853fe88f58621171b0f4d
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Link https://www.scopus.com/inward/record.uri?eid=2-s2.0-84976640760&doi=10.1039%2fc6ra13178f&partnerID=40&md5=c0abd66cff8853fe88f58621171b0f4d
Affiliations Postovsky Institute of Organic Synthesis of RAS (Ural Branch), Yekaterinburg, Russian Federation; Siberian State Medical University, Tomsk, Russian Federation; Russian National Research Tomsk Polytechnic University, Tomsk, Russian Federation; Mikheev Institute of Metal Physics of RAS (Ural Branch), Yekaterinburg, Russian Federation; Ural Centre for Shared Use Modern Nanotechnology, Institute of Natural Sciences, Ural Federal University, Yekaterinburg, Russian Federation
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Correspondence Address Pershina, A.G.; Siberian State Medical UniversityRussian Federation; email: allysyz@mail.ru
Publisher Royal Society of Chemistry
CODEN RSCAC
Language of Original Document English
Abbreviated Source Title RSC Adv.
Source Scopus