New fluorine-containing hypotensive preparations / Yagupolskii L.M., Maletina I.I., Petko K.I., Fedyuk D.V., Handrock R., Shavaran S.S., Klebanov B.M., Herzig S. // Journal of Fluorine Chemistry. - 2001. - V. 109, l. 1. - P. 87-94.

ISSN:

00221139

Type:

Article

Abstract:

The synthesis and pharmacological properties of a novel type of vasorelaxant hybrid compounds are described. The investigated compounds are based on fluorinated 4-aryl-1,4-dihydropyridines (1,4-DHP), which are known calcium channel blockers, and/or from fluorinated analogues of pinacidil, an opener of ATP-sensitive potassium channels. Benzimidazole analogues of hypotensive preparation losartan with fluorine-containing substituents in positions 2 and 5, as well as at heterocyclic nitrogen atom of benzimidazole ring are discussed. © 2001 Elsevier Science B.V. All rights reserved.

Author keywords:

Angiotensin ii receptor antagonists; Benzimidazole; Calcium and potassium channels modulators; Fluorine-containing substituents; Hypotensive preparations

Index keywords:

нет данных

DOI:

10.1016/S0022-1139(01)00382-7

Смотреть в Scopus:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0034915109&doi=10.1016%2fS0022-1139%2801%2900382-7&partnerID=40&md5=e7ff6c3612041cfe00a2bbbda8494d91

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Link	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0034915109&doi=10.1016%2fS0022-1139%2801%2900382-7&partnerID=40&md5=e7ff6c3612041cfe00a2bbbda8494d91
Affiliations	Institute of Organic Chemistry, Ukrainian Natl. Academy of Sciences, 02094 Murmanskaya Str. 5, Kiev, Ukraine; Institute of Pharmacology, University of Cologne, 509204, Cologne, Germany
Author Keywords	Angiotensin ii receptor antagonists; Benzimidazole; Calcium and potassium channels modulators; Fluorine-containing substituents; Hypotensive preparations
References	Negwer, M., (1971) Organic-Chemical Drugs and their Synonyms, , Academie, Berlin; Yagupolskii, L.M., (1988) Aromatic and Heterocyclic Compounds with Fluorine-Containing Substituents, , Naukova Dumka, Kiev; Kastron, V.V., Duburs, G.Y., Shatz, V.D., Yagupolskii, L.M., (1985) Arzneim. Forsch./Drug Res., 35 (1), p. 668; Kastron, V.V., Vitolina, R.O., Fialkov, Y.U.A., Shelyazhenko, S.V., Duburs, G.Y., Kimenis, A.A., Yagupolskii, L.M., US Patent 4 219 653 (1985); Kremlev, M.M., Moklyachuk, L.I., Fialkov, Y.U.A., Yagupolskii, L.M., Danilenko, V.S., Trinus, F.P., Chernoshtan, K.A., Endelman, E.S., Patent of Ukraine N 4369 (1994); Petko, K.I., Rechitskii, A.N., Maletina, I.I., Yagupolskii, L.M., (1996) Ukr. Khim. Zhurn., 62, p. 11; Maletina, I.I., Petko, K.I., Shavaran, S.S., Klebanov, B.M., Lozinski, M.O., Yagupolskii, L.M., (1997) Khim.-Farm. Zhurn., 31, p. 6; Yagupolskii, L.M., Antepohl, W., Artunc, F., Handrock, R., Klebanov, B.M., Maletina, I.I., Marxen, B., Herzig, S., (1999) J. Med. Chem., 42, p. 5266; Fedyuk, D.V., Maletina, I.I., Yagupolskii, L.M., (1997) Ukr. Khim. Zhurn., 63, p. 9; Fedyuk, D.V., Maletina, I.I., Yagupolskii, L.M., (1997) Ukr. Khim. Zhurn., 63, p. 11; Fedyuk, D.V., Maletina, I.I., Yagupolskii, L.M., (1999) Ukr. Khim. Zhurn., 65, p. 12; Burkholder, C., Dolbier, W.R., Medebielle, M.J., (1998) J. Org. Chem., 63, p. 5385; Yagupolskii, L.M., Fedyuk, D.V., (2000) Tetrahedron Lett., 41, p. 2265
Language of Original Document	English
Abbreviated Source Title	J. Fluor. Chem.
Source	Scopus