The effect of membrane channel agonists and antagonists on hemodynamics and vascular tonus [Vplyv ahonistiv i antahonistiv membrannykh kanaliv na hemodynamiku ta tonus sudyn.] / Shevchuk V.H., Iahupol's'kyi L.M., Shavaran S.S., Klebanov B.M., Zyma S.V. // Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994). - 1999. - V. 45, l. 1-2. - P. 35-39.

ISSN:

нет данных

Type:

Article

Abstract:

Compound "C" which was synthesized in Institute of Organic Chemistry NA of Science unite in one molecule remnant of 4-aril-1,4-dihydropyridin kernek cause it as calcium channel block-up property and group of molecule pinacidil which determine if effect as activation potassium channels. This compound cause essential decrease arterial pressure and total periphery resistance of vessels. The decrease this figures of hemodynamic connect with reducing vessels tone. This is proved by substantial decrease contractile activity isolated strips of aorta and portal vein by compound "C". The mechanism reducing tone, as demonstrate investigations on isolated solitary smooth muscle mesenterial arteries, cause with increase potassium current, hyperpolarization of cell's membrane, and with depresses calcium current in L-type Ca(2+) channels.

Author keywords:

Index keywords:

1,4 dihydropyridine; 1,4-dihydropyridine; calcium channel blocking agent; calcium channel stimulating agent; dihydropyridine derivative; ion channel; animal; article; drug effect; hemodynamics; physio

DOI:

нет данных

Смотреть в Scopus:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032616741&partnerID=40&md5=0ea2a5e7a95e1f5ffc11e683fa7b705e

Соавторы в МНС:

—

Другие поля

Поле	Значение
Link	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032616741&partnerID=40&md5=0ea2a5e7a95e1f5ffc11e683fa7b705e
Affiliations	National Medical University, Kiev.
Chemicals/CAS	1,4 dihydropyridine, 3337-17-5; 1,4-dihydropyridine, 3337-17-5; Calcium Channel Agonists; Calcium Channel Blockers; Dihydropyridines; Ion Channels
Correspondence Address	Shevchuk, V.H.
PubMed ID	10202634
Language of Original Document	Ukrainian
Abbreviated Source Title	Fiziol Zh
Source	Scopus