Action of nonsteroid antiinflammatory substances on the inflammation mediators / Klebanov B.M. // Farmakologiya i Toksikologiya. - 1979. - V. 42, l. 1. - P. 43-47.

ISSN:

00148318

Type:

нет данных

Abstract:

The action of nonsteroid antiinflammatory substances on the content in the inflammation focus of the inflammation reaction mediators, histamine, serotonin and kinines, and some aspects of their metabolism were studied. Sodium mephenaminate and butadion are shown to bring down the histamine content in the exudate of rats with experimental pleurisy. Sodium mephenaminate depresses the histamine synthesis (by inhibiting histidine decarboxylase in the pulmonary tissue), while butadion activates decomposition of this amine (by raising histaminase activity). All the studied compounds (except sodium mephenaminate) force down the serotonin level in the exudate and inhibit 5-hydroxytryptophan decarboxylase. The content of kininogen in the exudate decreases only under the influence of butadion. Sodium mephenaminate and butadion mitigate the reaction of the dermal vessels to exogenous histamine and serotonin and chingamine does so only in response to histamine.

Author keywords:

Index keywords:

chloroquine; histamine; kinin; mefenamic acid; phenylbutazone; serotonin; Anti Inflammatory Agents; antiinflammatory agent; bradykinin; chloroquine; histamine; indometacin; mefenamic acid; phenylbutaz

DOI:

нет данных

Смотреть в Scopus:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0018347648&partnerID=40&md5=5266678711457c251f93f73985ffd00a

Соавторы в МНС:

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Другие поля

Поле	Значение
Link	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0018347648&partnerID=40&md5=5266678711457c251f93f73985ffd00a
Affiliations	Lab. Chast. Farmakol., Inst. Farmakol. Toksikol., Min. Zdravookhr. Ukrain. SSR, Kiev, Ukraine
Chemicals/CAS	chloroquine, 132-73-0, 3545-67-3, 50-63-5, 54-05-7; histamine, 51-45-6, 56-92-8, 93443-21-1; mefenamic acid, 61-68-7; phenylbutazone, 129-18-0, 50-33-9, 8054-70-4; serotonin, 50-67-9; bradykinin, 58-82-2, 5979-11-3; indometacin, 53-86-1, 74252-25-8, 7681-54-1; salicylate sodium, 54-21-7; Anti-Inflammatory Agents; Bradykinin, 58-82-2; Chloroquine, 54-05-7; Histamine, 51-45-6; Indomethacin, 53-86-1; Mefenamic Acid, 61-68-7; Phenylbutazone, 50-33-9; Serotonin, 50-67-9; Sodium Salicylate, 54-21-7
Tradenames	butadion
CODEN	FATOA
PubMed ID	421890
Language of Original Document	Russian
Abbreviated Source Title	FARMAKOL. TOKSIKOL.
Source	Scopus